Tällainen paperi ilmestyi syksyllä:How Western Diet And Lifestyle Drive The Pandemic Of Obesity And Civilization Diseases
Miten länsimainen ruokavalio *) ja elämäntapa ovat aiheuttaneet lihavuuspandemian ja siihen liittyvät "elintasosairauksien" pandemiat (diabetes, sv-taudit, syöpä, autoimmuunisairaudet, Alzheimer ym.) tutkimuksessa kysytään.
No hapetusstressin, insuliiniresistenssin ja lievän tulehduksen välityksellä tietenkin.
*)länsimainen ruokavalio = korkean glykeemisen indeksin omaavaa runsashiilihydraattista ja runsaaasti omega-6-rasvahappoja sisältävää ruokaa (high-glycemic carbohydrate foods, like refined grains, sugar, corn, refined fructose, and foods that are high in omega-6 PUFAs).
Summary And Conclusions
-Over the course of 6–8 generations, but especially in the last 2–3 generations, there has been a pandemic of obesity and non-infectious degenerative diseases known as civilization diseases.
Among a variety of factors that may be involved in this development, Western diet and lifestyle, as well as epigenetic changes and fetal programming, are believed to play key roles.
-The evidence presented shows that Western diets significantly distort the fine-tuned metabolism that has evolved over a very long period of human evolution in adaptation to Paleolithic nutrition, including an increased production of ROS, insulin hypersecretion and IR, low-grade inflammation and an abnormal activation of SNS and RAS (displayed in Figure 1), which may cause or contribute to the development of civilization diseases.
-The suggested pathomechanism is also well-suited to explain the well-known but not completely understood close relationship between obesity and the wide range of comorbidities like T2DM, cardiovascular disease, cancer, etc., as diseases of the same etiopathology.
-With the increasing spread of Western diet and lifestyle worldwide, overweight and lifestyle diseases are also rapidly increasing in developing countries.
-As rates of obesity increase worldwide, a significant percentage of embryos and fetuses will be exposed to an overweight or obese in utero environment and likely to maternal overnutrition during key periods of perinatal development, making fetuses vulnerable to obesity and degenerative diseases later in life - a self-reinforcing process that further fuels the pandemic.
-Changing our lifestyle in accordance with our genetic constitution, including diet and physical activity, can help prevent or limit the development of these diseases. This view is underpinned by several human and animal intervention studies which show that diets composed of Mediterranean/Paleolithic foods such as meat, fish, eggs, fresh fruits and vegetables, roots, tubers, nuts and seeds have highly beneficial effects on risk factors for diseases of civilization.2,141–143,181
-Probably more important than the foods contained in these diets are foods that are not included, especially high-glycemic carbohydrate foods, like refined grains, sugar, corn, refined fructose, and foods that are high in omega-6 PUFAs. Therefore, quality rather than the quantity of dietary fat and carbohydrates are important.