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Full Title: Omega-6 Apocalypse 2: Are Seed Oil Excesses the Unifying Mechanism for Overweight and Virtually All Chronic Disease? - Chris Knobbe (AHS21)

Over the past 150 years, we’ve witnessed the evolution of pandemics of chronic degenerative, metabolic, and noncommunicable disease (NCD). Ample evidence supports the conclusion that coronary heart disease, cancers, metabolic disease, type 2 diabetes, obesity, age-related macular degeneration (AMD), and many other chronic diseases have risen from medical rarity to the most common causes of chronic disease and death. During this same time frame, we’ve witnessed industrially produced seed oils, rich in omega-6 fatty acids, elevate to occupy up to one-fourth to one-third of human consumption, or more. Such oils rarely existed anywhere prior to the American Civil War, globally. Virtually all chronic degenerative diseases have in common one primary metabolic defect, namely, mitochondrial dysfunction. Seed oil and high omega-6 is a known driver of mitochondrial dysfunction, as evidenced in many studies. Furthermore, an examination of food consumption patterns in many nations strongly indicates that seed oils are by far the greatest factor in such chronic disease. An examination of food consumption in Japan leads to no other obvious conclusion. Could omega-6 rich seed oils, consumed to excess, be the common precipitating factor for most all chronic disease, via multiple mechanisms, including the fact that they are pro-oxidative, proinflammatory, cytotoxic, genotoxic, mutagenic, atherogenic, thrombogenic, and obesogenic? The evidence is compelling.