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Higher levels of total cholesterol and iron and lower levels of glucose, creatinine, uric acid, aspartate aminotransferase, gamma-glutamyl transferase, alkaline phosphatase, lactate dehydrogenase, and total iron-binding capacity were associated with reaching 100 years.

I've spent my life as a professor at
UCLA/USC Medical schools training doctors.

One thing I regret having taught:

LIE #7: Statins are a good choice to prevent heart disease & strokes.

Audiobook now available.
(Kindle and physical books out soon)

https://www.robertlufkinmd.com/lies/

Statin Therapy Induces Gut Leakage and Neuromuscular Disjunction in Patients With Chronic Heart Failure

Journal of Cardiovascular Pharmacology 82(3):p 189-195, September 2023. | DOI: 10.1097/FJC.0000000000001445

Abstract
Statins are commonly used to limit the risk of cardiovascular diseases, including ischemic heart attack and stroke. However, treatment often leads to myopathy and muscle weakness. Therefore, a better understanding of underlying pathomechanism is needed to improve the clinical outcomes. Here, we assessed the physical performance, including handgrip strength (HGS), gait speed (GS), and short physical performance battery, in 172 patients diagnosed with chronic heart failure (CHF) treated with (n = 50) or without (n = 122) statin and 59 controls. The plasma biomarkers, including sarcopenia marker C-terminal agrin fragment-22 (CAF22), intestinal barrier integrity marker zonulin, and C-reactive protein (CRP), were measured and correlated with the physical performance of patients. The HGS, short physical performance battery scores, and GS were significantly compromised in patients with CHF versus controls. Irrespective of etiology, significant elevation of plasma CAF22, zonulin, and CRP was observed in patients with CHF. There were strong inverse correlations of CAF22 with HGS (r2 = 0.34, P < 0.0001), short physical performance battery scores (r2 = 0.08, P = 0.0001), and GS (r2 = 0.143, P < 0.0001). Strikingly, CAF22 and zonulin were positively correlated with each other (r2 = 0.10, P = 0.0002) and with the level of CRP in patients with CHF. Further investigations revealed a significant induction of CAF22, zonulin, and CRP in patients with CHF taking statin versus nonstatin group. Consistently, HGS and GS were significantly lower in the statin versus nonstatin CHF patients' group. Collectively, statin therapy adversely affects the neuromuscular junction and intestinal barrier, which potentially induces systemic inflammation and physical disability in patients with CHF. Further prospective confirmation of the findings is required in a well-controlled study.

Low Cholesterol Levels in Younger Heart Failure Patients May Predict Unfavorable Outcomes


Medicina 2023, 59(7), 1314; https://doi.org/10.3390/medicina59071314
Received: 9 May 2023 / Revised: 5 July 2023 / Accepted: 12 July 2023 / Published: 16 July 2023
(This article belongs to the Section Cardiology)

Abstract
Background and Objectives: Hypercholesterolemia is a main risk-factor leading to ischemic heart disease (IHD). However, among patients with heart failure, the use of lipid lowering drugs in the presence of low cholesterol might be dangerous. This 18-year longitudinal study of patients ≤51 years old investigated the relationship between baseline total cholesterol, low-density lipoprotein cholesterol (LDL-c) and triglyceride levels, and survival among patients with severe HF. Materials and Methods: The average NYHA score of 82 patients ≤51 years old with heart failure was 2.61. They were followed for a mean of 11.3 years (15 months–20 years). Total mortality was 22%. Patients were divided into three groups. Group 1 had plasma LDL-c levels ≤ 80 mg/dl, Group 2, 80–115 mg/dl and Group 3 > 115 mg/dl. Results: Patients with the highest baseline total cholesterol, triglyceride and LDL-c levels > 115 mg/dl had a better survival rate (83%) compared to those with LDL-c < 80 mg/dl (50% survival, p = 0.043). The association between higher LDL-c levels and lower mortality was most noticeable among patients with heart failure. Conclusion: Longitudinal follow-up found that low LDL-c levels may indicate poorer prognosis among patient with heart failure who are ≤51 years old, similar to elderly heart failure patients. Cholesterol lowering drugs in younger patients with heart failure may increase mortality.

Not Getting Enough Sleep? Your Vascular Cells Are Drowning in Oxidants

I often receive questions about phytosterols & their probable connection to Atherosclerosis.

#plant-based adherents often promote these plant sterols for their lowering effect.

If these sterols are PER SE atherogenic, that seems quite DANGEROUS.

A look at the evidence 1/12

Conclusions In adults with coronary artery disease, rosuvastatin and atorvastatin showed comparable efficacy for the composite outcome of all cause death, myocardial infarction, stroke, or any coronary revascularisation at three years. Rosuvastatin was associated with lower LDL cholesterol levels but a higher risk of new onset diabetes mellitus requiring antidiabetics and cataract surgery compared with atorvastatin.

lievä pitkittynyt univaje aiheuttaa sydänsairautta”, tutkimusta johtanut professori Sanja Jelic sanoo Columbian yliopiston tiedotteessa.

Your liver produces 70-80% of total cholesterol in the body. To think that cholesterol, a molecule that is so essential that the body makes 80% of it, is bad for your health is the dumbest concept that western medicine has come up with.

Cholesterol is a crucial component of cell membrane structure and plays a vital role in various physiological functions such as hormone synthesis, vitamin D synthesis, bile acid synthesis, and transmission of signals between nerve cells. Cholesterol is also involved in the immune system, inflammation and tissue repair after an injury.

Blocking our liver from making cholesterol or restricting dietary cholesterol makes zero sense to me. Coronary artery disease is NOT caused by cholesterol. Cholesterol is there to try to fix damage caused by something else. That something else is chronic inflammation and metabolic diseases. Diabetes, obesity, and hypertension are a much greater risk than cholesterol. Cholesterol can become part of the problem when there is too much damage to repair and builds up in a plaque, but cholesterol was never the cause.