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ViestiLähetetty: 2022-01-18 15:16:50 
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Liittynyt: 2007-05-25 15:55:11
Viestit: 29210
Hiiritutkimus. Keto edisti aivovaurion seurauksena heikentyneiden kognitiivisten kykyjen palautumista. Yli puolet palautui kahden kuukauden ketoilulla.

https://pubmed.ncbi.nlm.nih.gov/34876621/

Lainaa:
Ketogenic Diet as a potential treatment for traumatic brain injury in mice
Meirav Har-Even et al. Sci Rep. 2021.
Free PMC article

Abstract

Traumatic brain injury (TBI) is a brain dysfunction without present treatment. Previous studies have shown that animals fed ketogenic diet (KD) perform better in learning tasks than those fed standard diet (SD) following brain injury. The goal of this study was to examine whether KD is a neuroprotective in TBI mouse model. We utilized a closed head injury model to induce TBI in mice, followed by up to 30 days of KD/SD. Elevated levels of ketone bodies were confirmed in the blood following KD. Cognitive and behavioral performance was assessed post injury and molecular and cellular changes were assessed within the temporal cortex and hippocampus. Y-maze and Novel Object Recognition tasks indicated that mTBI mice maintained on KD displayed better cognitive abilities than mTBI mice maintained on SD. Mice maintained on SD post-injury demonstrated SIRT1 reduction when compared with uninjured and KD groups. In addition, KD management attenuated mTBI-induced astrocyte reactivity in the dentate gyrus and decreased degeneration of neurons in the dentate gyrus and in the cortex. These results support accumulating evidence that KD may be an effective approach to increase the brain's resistance to damage and suggest a potential new therapeutic strategy for treating TBI.


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ViestiLähetetty: 2022-01-18 15:21:47 
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ruutana
ruutana

Liittynyt: 2007-05-25 15:55:11
Viestit: 29210
Tutkimusuutinen Times of Israelissa:

https://www.timesofisrael.com/high-fat- ... eli-study/

Lainaa:
High-fat diet may restore cognitive function lost in brain injury – Israeli study
More than half of the lost cognitive ability returns after mice are given ketogenic diet for two months, Tel Aviv University scientists report in peer-reviewed research

By NATHAN JEFFAY
17 Jan 2022, 3:45 pm

A high-fat, low-carb nutrition regime known as the ketogenic diet significantly reduces the cognitive effects of brain injury in mice, and may do the same for humans, according to Israeli scientists.


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