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Aloita uusi ketju  Vastaa viestiin  [ 2 viestiä ] 
Julkaisija Viesti
ViestiLähetetty: 2021-04-22 06:41:54 
Poissa
ruutana
ruutana

Liittynyt: 2007-05-25 15:55:11
Viestit: 24525
Plasman greliiniä alentava vaikutus on ilmeisesti ainakin osa selitystä sille, että keto auttaa hillitsemään ruokahalua, mikä tekee laihduttamisen ja paastoilun helpommaksi.

Acute ketosis inhibits appetite and decreases plasma concentrations of acyl ghrelin in healthy humans

Lainaa:
Abstract
Context
Ketosis appears to decrease appetite and facilitate weight loss. Potential underlying mechanisms include decreases in plasma levels of the orexigenic hormone ghrelin and increases in appetite‐inhibiting glucagon‐like peptide‐1 (GLP‐1) levels. The effect of acute ketosis as compared to an isocaloric and isovolumetric beverage on both acyl ghrelin and total GLP‐1 plasma concentrations has not been previously measured.

Objective
We aimed to investigate the acute effect of ketone ester (KE) ingestion on appetite and plasma concentrations of acyl ghrelin (AG), unacylated ghrelin (UAG), and GLP‐1 secretion and to compare responses to those elicited by isocaloric glucose administration.

Methods
We examined ten healthy young males on three separate occasions using a placebo‐controlled crossover design.

Interventions and Main outcome Measures.
A KE vs. taste‐matched isovolumetric and isocaloric 50% glucose (GLU) and taste‐matched isovolumetric placebo vehicle (PBO) was orally administered. Our main outcome measures were plasma concentrations of AG, UAG, glucose‐dependent insulinotropic polypeptide (GIP), and GLP‐1 along with appetite sensation scores assessed by visual analogue scale .

Results
KE ingestion resulted in an average peak ꞵ‐hydroxybutyrate concentration of 5.5 mM. AG and UAG were lowered by ~25% following both KE and GLU intake, compared with PBO. In the case of AG, the differences were − 52.1 [−79.4–24.8] for KE and − 48.4 [−75.4, −21.5] pg/mL for GLU intake, p < 0.01. Concentrations of AG remained lower with KE, but returned to baseline and were comparable with PBO levels after GLU intake. Neither GLP‐1, GIP, gastrin or cholecystokinin were affected by KE ingestion.

Discussion
Our results suggest that the suppressive effects on appetite sensation scores associated with hyperketonemia are more likely to be mediated through reduced ghrelin concentrations than by increased activity of cholecystokinin, gastrin, GIP, or GLP‐1.


Ylös
   
ViestiLähetetty: 2021-04-26 13:21:25 
Poissa
ruutana
ruutana

Liittynyt: 2007-05-25 15:55:11
Viestit: 24525
Tuore tutkimuskatsaus toteaa saman asian

Ketogenic diets and appetite regulation

Lainaa:
Abstract
Purpose of review
The popularity of ketogenic diets in the treatment of obesity has increased dramatically over the last years, namely due to their potential appetite suppressant effect. The purpose of this review was to examine the latest evidence regarding the impact of ketogenic diets on appetite.

Recent findings
The majority of the studies published over the last 2 years adds to previous evidence and shows that ketogenic diets suppress the increase in the secretion of the hunger hormone ghrelin and in feelings of hunger, otherwise see when weight loss is induced by non-ketogenic diets. Research done using exogenous ketones point out in the same direction. Even though the exact mechanisms by which ketogenic diets suppress appetite remain to be fully determined, studies show that the more ketotic participants are (measured as β-hydroxybutyrate plasma concentration), the smaller is the increase in ghrelin and hunger and the larger is the increase in the release of satiety peptides. Further evidence for a direct effect of ketones on appetite comes from studies using exogenous ketones.

Summary
The appetite suppressant effect of ketogenic diets may be an important asset for improving adherence to energy restricted diets and weight loss outcomes.


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