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Liittynyt: 2007-05-25 15:55:11
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Systematic Review ‐ Neuroprotection of ketosis in acute injury of the mammalian central nervous system: A meta‐analysis

Lainaa:
Abstract
To evaluate the neuroprotection exerted by ketosis against acute damage of the mammalian central nervous system (CNS). Search engines were interrogated to identify experimental studies comparing the mitigating effect of ketosis (intervention) versus non‐ketosis (control) on acute CNS damage. Primary endpoint was a reduction in mortality. Secondary endpoints were a reduction in neuronal damage and dysfunction, and an ‘aggregated advantage’ (composite of all primary and secondary endpoints). Hedges' g was the effect measure. Subgroup analyses evaluated the modulatory effect of age, insult type, and injury site. Meta‐regression evaluated timing, type, and magnitude of intervention as predictors of neuroprotection. The selected publications were 49 experimental murine studies (period 1979–2020). The intervention reduced mortality (g 2.45, SE 0.48, p < .01), neuronal damage (g 1.96, SE 0.23, p < .01) and dysfunction (g 0.99, SE 0.10, p < .01). Reduction of mortality was particularly pronounced in the adult subgroup (g 2.71, SE 0.57, p < .01). The aggregated advantage of ketosis was stronger in the pediatric (g 3.98, SE 0.71, p < .01), brain (g 1.96, SE 0.18, p < .01), and ischemic insult (g 2.20, SE 0.23, p < .01) subgroups. Only the magnitude of intervention was a predictor of neuroprotection (g 0.07, SE 0.03, p 0.01 per every mmol/L increase in ketone levels). Ketosis exerts a potent neuroprotection against acute damage to the mammalian CNS in terms of reduction of mortality, of neuronal damage and dysfunction. Hematic levels of ketones are directly proportional to the effect size of neuroprotection.



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ViestiLähetetty: 2021-04-13 19:15:02 
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ruutana
ruutana

Liittynyt: 2007-05-25 15:55:11
Viestit: 29218
Blogiartikkeli selvittää asiaa:

Can Ketones Protect Against Brain Injury?

Lainaa:
Ketones may offer neuroprotection by:

• Delivering a high-energy fuel source (increasing ATP after injury)
• Reducing oxidative stress
• Lowering neuroinflammation
• Increasing GABA (calming neurotransmitter)/reduced glutamate
• Increasing brain-derived neurotrophic factor (BDNF)
• Increasing cerebral blood flow
• Lowering blood sugar, which may be important due to the deleterious effects of hyperglycemia on the injured brain


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Aloita uusi ketju  Vastaa viestiin  [ 2 viestiä ] 

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