Results:
There were 1580 respondents. The majority of respondents had consumed less than 100 g of carbohydrates per day for over a year, typically for reasons of weight loss or disease management. There was a reported decrease in waist circumference and weight with a simultaneous decrease in hunger and increase in energy level. Of those who provided laboratory values, the majority saw improvements in their HbA1c, blood glucose measurements, and lipid panel results. There was a reduction in usage of various medications, and 25% reported medication cost savings, with average monthly savings of $288 for those respondents. In particular, the usage of pain relievers and antiinflammatories dropped with a simultaneous decreased rating of pain and increase in mobility. Conclusion: We conclude that low-carbohydrate diets are a sustainable method of metabolic syndrome reversal in a community setting.

Conclusion

Currently recommended drug treatments, nutritional guidelines and behavioural interventions have had limited to no success in halting the obesity and diabetes epidemics. This has resulted in exorbitant health care costs122 and indirect costs from lower quality of life123 and lost productivity124 for a growing proportion of the population. The premise of this research project is that excess carbohydrate intake in the Western diet is a major driver of the obesity and diabetes epidemics, and that restricting dietary carbohydrate to a level that permits utilisation of fat as the primary fuel will yield substantial weight loss and improvement in diabetes and metabolic syndrome, other health conditions and overall quality of life. Moreover, we show that for many, a lowcarbohydrate diet is satisfying and sustainable.

Conclusion

Currently recommended drug treatments, nutritional guidelines and behavioural interventions have had limited to no success in halting the obesity and diabetes epidemics. This has resulted in exorbitant health care costs122 and indirect costs from lower quality of life123 and lost productivity124 for a growing proportion of the population. The premise of this research project is that excess carbohydrate intake in the Western diet is a major driver of the obesity and diabetes epidemics, and that restricting dietary carbohydrate to a level that permits utilisation of fat as the primary fuel will yield substantial weight loss and improvement in diabetes and metabolic syndrome, other health conditions and overall quality of life. Moreover, we show that for many, a lowcarbohydrate diet is satisfying and sustainable.

Beyond helping people reduce their weight and get control of their blood glucose, ketogenic diets may also be heart-healthy, thanks to improvements in triglycerides, high-density lipoprotein (HDL) cholesterol levels, abdominal circumference, and blood pressure.

Results:

At 32 weeks, participants in the intervention group reduced their HbA1c levels more (estimated marginal mean [EMM] –0.8%, 95% CI –1.1% to –0.6%) than participants in the control group (EMM –0.3%, 95% CI –0.6% to 0.0%; P=.002). More than half of the participants in the intervention group (6/11, 55%) lowered their HbA1c to less than 6.5% versus 0% (0/8) in the control group (P=.02). Participants in the intervention group lost more weight (EMM –12.7 kg, 95% CI –16.1 to –9.2 kg) than participants in the control group (EMM –3.0 kg, 95% CI –7.3 to 1.3 kg; P<.001). A greater percentage of participants lost at least 5% of their body weight in the intervention (10/11, 90%) versus the control group (2/8, 29%; P=.01). Participants in the intervention group lowered their triglyceride levels (EMM –60.1 mg/dL, 95% CI –91.3 to –28.9 mg/dL) more than participants in the control group (EMM –6.2 mg/dL, 95% CI –46.0 to 33.6 mg/dL; P=.01). Dropout was 8% (1/12) and 46% (6/13) for the intervention and control groups, respectively (P=.07).

Conclusions:

Individuals with type 2 diabetes improved their glycemic control and lost more weight after being randomized to a very low-carbohydrate ketogenic diet and lifestyle online program rather than a conventional, low-fat diabetes diet online program. Thus, the online delivery of these very low-carbohydrate ketogenic diet and lifestyle recommendations may allow them to have a wider reach in the successful self-management of type 2 diabetes.

Virta Healthin ainutlaatuisen kliinisen kokeen ensimmäisen vuoden tulokset T2D:n hoidosta ohjatulla ketokarppauksella:

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-60 prosenttia asiakkaista sai tyypin 2 diabeteksensa remissioon.

-94 prosenttia pääsi eroon insuliinilääkityksestään tai saattoi pienentää annostusta.

-83 prosenttia ohjelman aloittaneista oli mukana vuoden kuluttua.

Muita vaikutuksia: Verenpaine laski, inflammaatio väheni, sv-tautien riskitekijöiden markkerit paranivat, insuliiniresistenssi väheni ja paino putosi.

Ja perästä kuuluu, tutkimus tulee kestämään yhteensä 2,5 vuotrta.